Nanoparticles as a Tool for Broadening Antifungal Activities.
Renzi, Daniele Fernanda de Almeida Campos, Laís Miranda, Eduardo Hösel Mainardes, Rubiana Mara Abraham, Wolf-Rainer Grigoletto, Diana Fortkamp Khalil, Najeh Maissar
Renzi, Daniele Fernanda
de Almeida Campos, Laís
Miranda, Eduardo Hösel
Mainardes, Rubiana Mara
Abraham, Wolf-Rainer
Grigoletto, Diana Fortkamp
Khalil, Najeh Maissar
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Abstract
Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance, new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.
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Keywords
Azoles, echinocandins, fungal infection, infectious
disease, nano partice drug delivery, nanotechnology, polyenes